PROTAC 54 (Table 12) could effectively induce degradation of EGFRDel19 with DC50 value of 3.57 nM in HCC-827 cells, but not to other EGFR mutant, wild-type EGFR protein and the same family receptors (HER2 and HER4). This evidence concerns the gene EGFR and hepatocellular carcinoma.