We found that SLE-dysregulated genes were highly enriched in signaling pathways, including regulation of type I interferon-mediated signaling pathway, response to hypoxia, regulation of MAPK (mitogen-activated protein kinase) cascade, response to steroid hormone, complement and coagulation cascades, and Th1 and Th2 cell differentiation (Fig. 2a). The gene discussed is WNK2; the disease is systemic lupus erythematosus.