In addition, YAP/TAZ can regulate the production of secretory proteins, such as amphiregulin (AREG; an epidermal growth factor (EGF) family member), cysteine-rich angiogenic inducer 61 (CYR61), and connective tissue growth factor (CTGF), to influence the tumor microenvironment [39]. This evidence concerns the gene CCN2 and neoplasm.