These results were further confirmed in TC cultures from size-matched follicles of PCOS women and Controls, in which the authors also demonstrated a significant increase in the transcriptional expression of CYP17 and CYP11a, as well as in CYP17, 3βHSD and cytochrome P450 activity [6, 29]. Here, CYP17A1 is linked to polycystic ovary syndrome.