Similarly, adipocyte expression of resistin has been shown to be higher in PCOS women with hyperandrogenism [43], and its plasma concentration positively correlated with testosteronemia in PCOS patients but not in Controls, evoking the possibility that polycystic ovary TC are more sensitive to the action of resistin, which, by interacting with insulin, could contribute to androgen hyperproduction [44]. This evidence concerns the gene INS and hyperandrogenism.