CYP21A2 and hyperandrogenism: Indeed, the genes most frequently and significantly associated with this syndrome include several molecules involved in androgen metabolism, such as CYP11A, CYP21 [30] and, particularly, DENND1Av.2, a gene coding for a clathrin-binding protein that seems to play a key role in PCOS-associated hyperandrogenism by increasing CYP17A1 and CYP11A1 genes transcription [5, 31].