RARRES2 and hyperandrogenism: Considering these results and the fact that, in vitro, testosterone stimulation of human GC resulted in an overexpression of both chemerin and its receptors [40], Lima et al. suggested that hyperandrogenism might induce an increase in chemerin ovarian levels, which, in turn, might act as a chemoattractant for circulating CMKLR1+ monocytes [41].