While some studies have shown that STZ increased BACE1 levels, leading to Aβ generation in the brains of APP/PS1 mice [18], other studies revealed that STZ increased Aβ generation independently of BACE1 in APP transgenic mice and a monkey model of T1DM induced by injection of STZ [17, 37]. The gene discussed is BACE1; the disease is type 1 diabetes mellitus.