While in PCa restaging, radiomics and AI can improve the interpretation of PET/CT images to identify BCR by discerning post-radiotherapy necrotic tissue from tumor tissue, to automatically recognize patients without disease recurrence from patients with locoregional-distant recurrence, to automatically classify bone lesions as degenerative or metastatic lesions, but also to predict disease progression in PCa patients at high BCR risk. The gene discussed is BCR; the disease is posterior cortical atrophy.