Finally, in 2021, Hinzpeter et al. [74] investigated the potential application of RFs analysis using an ML-based radiomics algorithm for detecting bone metastases not visible on low-dose CT, extracting from [68Ga]Ga-PSMA-11 PET imaging of 67 patients with PCa as the reference standard (ground truth). This evidence concerns the gene FOLH1 and posterior cortical atrophy.