FADS1 and type 2 diabetes mellitus: Taken together, since the FADS1 has shown to regulate the activity of enzymes or their eicosanoids these results suggest that LA-enriched diet induces AT inflammation in those with the TT genotype, the genotype known to be associated with the T2D [47], possibly via the increased levels of enzymes responsible for the biosynthesis of pro-inflammatory eicosanoids.