FADS1 and metabolic dysfunction-associated steatotic liver disease: Furthermore, a reduced FADS1 function, due to the CC genotype of FADS1-rs174550 with a lower desaturase activity, has been shown to associate positively with hepatic inflammation, non-alcoholic fatty liver disease and to induce changes in n-6 and n-3 PUFA-derived eicosanoid levels in a mouse model and in a human study [17, 18].