IDH1 and central nervous system cancer: The mean number of DMPs within IDH-mutant glioma was 16,649 (max: 46,445, min: 3609) and the number of intratumor DMPs were significantly increased in IDH-mutant gliomas of CNS WHO grade 3–4 (mean number of intratumor DMPs: 22,918) compared to CNS WHO grade 2 tumors (mean number of intratumor DMPs: 8289).