CDKN1B and squamous cell carcinoma: A study using sublines of human squamous cell carcinoma cell line HEp3, proliferative T-HEp3 and quiescent D-HEp3, identified the orphan nuclear receptor NR2F1 as a key regulator of TME-mediated cellular quiescence, and revealed that SOX9, RARβ, and cyclin-dependent kinase inhibitors, including p27 (CDKN1B), are involved in cellular quiescence6,7.