More importantly, ECN-pE(C/A)2 treatment could remarkably relieve DSS-induced acute IBD, including rapid body weight recovery, alleviated mucosa damage in colon tissue, and decreased colonic MPO activity, whereas other control groups, including ECN-pE without chitosan/sodium alginate coating or ECN(C/A)2 without expression of CAT and SOD, failed to protect the mice against acute IBD. Here, SOD1 is linked to inflammatory bowel disease.