Interestingly, we found significant correlation between serum cytokines and levels of AT1-AA in our cohort of PD patients but not in non-PD controls, suggesting that mechanisms related to PD, particularly PD-related increase in circulating AT1-AA, may contribute to the increase in levels of peripheral inflammatory cytokines by activating AT1 receptors of peripheral cells, which is known to induce production of proinflammatory cytokines in different tissues. The gene discussed is AGTR1; the disease is Parkinson disease.