We also identified SNPs near the APOE gene at 19q13.32 to be associated with Alzheimer’s disease and dementia; of these, we replicated a previously reported SNP, rs429358, as our most statistically significant SNP (discovery eMERGE p-value: 1.604 × 10−74, replication UKBB p-value: 6.327 × 10−54) associated with Alzheimer’s disease31. The gene discussed is APOE; the disease is early-onset autosomal dominant Alzheimer disease.