Those SNPs mapped to a region containing the genes APOC1, APOC1P1, TOMM40, APOE, and NECTIN2. All SNPs are associated with atherosclerotic heart disease, Alzheimer’s disease, and dementia, while 14 SNPs are also associated with angina pectoris and 18 SNPs are associated with delirium. This evidence concerns the gene APOE and early-onset autosomal dominant Alzheimer disease.