Finally, we also identified the rs16998073 locus (3 SNPs) near PRDM8/FGF5 at chromosome 4q21.21 that are associated with essential hypertension and severe depressive episode with psychotic symptoms from UKBB, with a risk genetic effect on both diseases (Supplementary Data 3, regional LD in Supplementary Fig. 3D). This evidence concerns the gene PRDM8 and essential hypertension.