HNF4A and metabolic dysfunction-associated steatotic liver disease: Consistently, the expression of target genes of HNF4α and C/EBPα (two essential transcription factors participating in the regulation of NAFLD-related metabolism genes)71 in the liver of HFD- and normally fed pigs was also comparable (P > 0.05, Wilcoxon rank-sum test) (Supplementary Fig. S14b).