However, Col1a2+/p.G610C bones had less high‐density bone in the least mature region (close to the growth plate), more low‐density bone in the most mature region (near the diaphysis) and a higher proportion of mid‐density bone along the full length of the metaphysis, indicating region‐specific differences in cortical bone maturation in this model of OI. This evidence concerns the gene COL1A2 and osteogenesis imperfecta.