Therefore, impaired mitochondrial health and quality control mechanisms are key derangements of CC and other atrophic conditions (White et al. 2012; Tzika et al. 2013; Puppa et al. 2014; Aversa et al. 2016; Brown et al. 2017b; Lee et al. 2020; Ballarò et al. 2021; Rosa-Caldwell et al. 2021), suggesting PGC-1α may be a compelling target to protect from cancer-induced muscle atrophies. Here, PPARGC1A is linked to cancer.