We previously observed changes in protein and mRNA levels of Deptor and Redd1 in both male and female LLC tumorbearing mice (Brown et al. 2018; Lim et al. 2022), suggesting inductions of these anabolic repressors may be responsible for noted impairments in protein synthesis in tumor-bearing mice (White et al. 2012; Brown et al. 2018; Lim et al. 2022). The gene discussed is DDIT4; the disease is neoplasm.