TP53 and acute myeloid leukemia: Genetic alterations in AML can be divided into three groups: 1) cytogenic abnormalities such as translocations, inversions, deletions, trisomies and monosomies, 2) cytogenetically normal but with gene mutations, such as in NPM1, FLT3, CEPBA, RAS, WT1, and TP53 and 3) epigenetic mutations, such as DNMT3A, IDH1/2, and TET (C).