In regards to the PCOS setting, serum levels of several members of the CTRP family are altered, showing an association with the disease pathogenicity, including CTRP3 [27], CTRP6 [28], CTRP9 [1], CTRP12, and CTRP13 [29]. This evidence concerns the gene C1QTNF12 and polycystic ovary syndrome.