Whereas EPCR is abundantly expressed on healthy endothelial cells, endothelial dysfunction may enhance proteolytic receptor shedding (57), and significantly higher baseline sEPCR levels have been observed in patients with ST elevation myocardial infarction compared with patients with stable angina pectoris (58) or in diabetic patients with platelet calpain-induced thromboinflammatory PAR1 activation (12). This evidence concerns the gene PROCR and endothelial dysfunction.