RB1 and pancreatic insulinoma: We found that the Bisque4 module membership gene set was indeed significantly enriched in predicted targets of the DREAM (fold enrichment [FE] = 3.4-fold, P = 4.1 × 10–15), MMB-FOXM1 (FE = 7.8, P = 1.2 × 10–19), and RB-E2F complexes (FE = 3.3, P = 3.7 × 10–8), suggesting that these pathways may serve as the key gatekeepers for β cell quiescence and modulators of insulinoma proliferation (Supplemental Figure 4 and Supplemental Table 3).