CDH17 and Familial exudative vitreoretinopathy: It has been reported that α-catenin inhibits Wnt signaling by segregating the available pool of β-catenin in cytosol, and that variants of α-catenin disrupt the cadherin/catenin complex that releases β-catenin from cytosol for nuclear translocation and activation of β-catenin signaling, which may contribute to the pathogenesis of FEVR (20, 67–70).