MøFoxO1 KO also resulted in a significant reduction in hepatic expression of Mttp and Apob (Figure 4H), 2 key lipid-binding proteins in VLDL-TG production, secondary to the reduction in hepatic steatosis and improvement of insulin sensitivity in HFD-fed MøFoxO1-KO mice. The gene discussed is MT-TP; the disease is Hepatic steatosis.