GPT and steatosis: However, this NASH diet–induced hepatic inflammation, steatosis, and fibrosis were significantly improved, along with mitigation of hepatic injury, as reflected in the reduction in serum ALT levels in MøFoxO1-KO mice (52 ± 8 versus 129 ± 16 IU/L in WT littermates, P < 0.001) (Figure 6, A–E).