Consistent with the improvement of hepatic inflammation, NASH diet–fed MøFoxO1-KO mice, relative to NASH diet–fed WT littermates, had a significant upregulation of hepatic expression of IL-4, IL-10, and Arg1 that are characteristic of M2 macrophages, accompanied by a significant downregulation of Trem2 and Ccr2, characteristic of M1 macrophages (Supplemental Figure 6). This evidence concerns the gene IL4 and metabolic dysfunction-associated steatohepatitis.