To gain further mechanistic insight into the protective action of myeloid FoxO1 deficiency against overnutrition-induced NASH, we performed comparative liver transcriptome analysis of RNA-Seq data, detecting a total of 342 DEGs in NASH diet–fed MøFoxO1-KO versus WT littermates. This evidence concerns the gene FOXO1 and metabolic dysfunction-associated steatohepatitis.