Variants in MT-ATP6 have been shown to cause a number of symptoms such as ataxia, cognitive dysfunction, neuropathy, seizures, and retinopathy; however, it is most commonly known to cause mitochondrial complex V deficiency, Leigh syndrome, and/or neuropathy, ataxia and retinitis pigmentosa (NARP) [32]. Here, MT-ATP6 is linked to NARP syndrome.