SGCG and autoimmune thrombocytopenic purpura: The proposed mechanism of the upregulated necroptosis markers in ITP patients is related mainly to the defective clearance of necroptotic cells and release of their contents as DAMPs that induce sterile inflammatory response and release of cytokines such as type I and type III IFNs [40] leading to cytokine imbalance which is a form of the immune cellular dysregulations participating in ITP pathogenesis [41].