MLKL and autoimmune thrombocytopenic purpura: Patients with severe thrombocytopenia displayed significantly higher expression levels of MLKL and Beclin-1 than those who had moderate thrombocytopenia, indicating a causal role of both necroptosis and autophagy markers in the development of thrombocytopenia in ITP patients and confirming that ITP severity is driven by several mechanisms.