The mean expression levels of RIPK3, MLKL and Beclin-1 mRNA were significantly upregulated in ITP patients (2.87, 3.31 and 3.94, respectively) compared with their levels in healthy control subjects (1.00, 1.01 and 1.00, respectively) at P < 0.001 (Table 2). This evidence concerns the gene BECN1 and autoimmune thrombocytopenic purpura.