The fold-reduction in geometric mean of T cell response (SFC) against B.1.1.529 (Omicron) S1 compared to ancestral Wuhan Hu-1 S1 protein was 17.3-fold for infection-naïve HCW (blue, p < 0.0001), 7.7-fold for previously Wuhan Hu-1 infected (red, p = 0.001), 8.5-fold for previously B.1.1.7 (Alpha) infected (green, p = 0.002) and 19-fold for previously B.1.617.2 (Delta) infected (purple, p = 0.0625) HCW (Fig. 2B). The gene discussed is PSMD1; the disease is infection.