REN and alcoholic liver diseases: Functional annotation of the downregulated cluster revealed these proteins to be involved in fat digestion and absorption, alcoholic liver disease, the adipocytokine signaling pathway, protein processing in the endoplasmic reticulum, glycerophospholipid metabolism, the NOD-like receptor signaling pathway, drug metabolism-cytochrome P450, renin secretion, pyrimidine metabolism, arginine and proline metabolism, metabolism of xenobiotics by cytochrome P450, and circadian rhythm (Fig. 4E).