RARA and acute promyelocytic leukemia: These nuclear dot-like structures were first identified in acute promyelocytic leukemia (APL) patients, where the PML gene is fused to the retinoic acid receptor α (RARα) gene due to the consistent chromosomal translocation t(15:17) (11), resulting in the disruption of the PML-NBs by the oncogenic PML-RARα fusion protein (3).