GNAL and Dystonia: Our results suggest that in a type of dystonia with a primary striatal dysfunction (Pelosi et al., 2017) the hyperexcitability of the cerebello-thalamic tract could reveal an increased susceptibility to dystonia, already present in presymptomatic Gnal+/- mice and further potentiated after the first dystonic episode; a decrease in functional connectivity could however correspond to a long-term adaptation of the cerebello-forebrain pathways, which did not take place in the timescale of our experiments.