Research on the genomic landscape of HCC has led to the identification of several significantly mutated genes, including the tumor suppressor genes TP53, AXIN1, and RB1; the WNT pathway oncogene CTNNB1; and the chromatin remodeling genes ARID1A, ARID2, and BAP132,58,59. The gene discussed is CTNNB1; the disease is hepatocellular carcinoma.