PDIA3 and amyotrophic lateral sclerosis: Indeed, it was found that the expression and function of ERp57 could be modulated under conditions of oxidative stress in neuronal cells in culture and in a PD animal model (Aureli et al., 2014; Giamogante et al., 2018), suggesting a feedback loop mechanism, and that ERp57 has a protective role to motor function in early stages of ALS progression, preserving the neuromuscular junction (Rozas et al., 2021) and in prion neurotoxicity (Hetz et al., 2005; Thapa et al., 2018).