Cognitive features were the most common clinical cerebral phenotype for 4 of 7 genes (HTRA1HomZ, COL4A2, HTRA1HetZ, and CTSA); stroke was the most common among individuals with COL4A1 and ADA2, and headache was most common among individuals with TREX1 (Figure 3, Table S1). Here, CTSA is linked to stroke disorder.