CTSA and stroke disorder: Ischemic events (including arterial and venous ischemic stroke, transient ischemic attacks, and ocular vascular occlusions) were most common for all other genes and were reported in 54% to 100% of stroke cases (HTRA1HomZ, 54% [7/13]; ADA2, 61% [70/115]; HTRA1HetZ, 62% [27/43]; TREX1, 82% [9/11]; CTSA, 100% [7/7]), although hemorrhagic events also occurred in a substantial minority.