Cognitive features were the most common clinical cerebral phenotype for 4 of 7 genes (HTRA1HomZ, COL4A2, HTRA1HetZ, and CTSA); stroke was the most common among individuals with COL4A1 and ADA2, and headache was most common among individuals with TREX1 (Figure 3, Table S1). The gene discussed is COL4A2; the disease is Stroke.