SNRNP70 and mixed connective tissue disease: In 2019, a revised diagnostic criterion for MCTD was made in Japan and it included four requirements: Raynaud's phenomenon, presence of anti-U1-RNP antibody, organ involvement (including pulmonary arterial hypertension and aseptic meningitis), and an overlapping feature of either SLE, systemic sclerosis, polymyositis, or dermatomyositis [3].