In estrogen-positive (ER+) human breast cancer Bca cells, diosgenin inhibits serine/threonine protein kinase (Akt) activity and also pAkt expression and inhibits the expression of apoptosis-inhibiting proteins Survivin and X-linked inhibitor of apoptosis protein, thereby inhibiting the proliferation of Bca cells [34]. The gene discussed is XIAP; the disease is breast cancer.