AKT1 and hepatocellular carcinoma: Diosgenin may induce cycle arrest of human hepatocelluar carcinoma (HCC) SMMC-7721 cell line by inhibiting the expressions of p21 and p27 upregulated by phosphatidylinositol-4,5-bisphosphate 3-kinase/protein kinase B (PI3K/Akt) and inhibiting the proliferation of human HCC SMMC-7721 cells [19].