PTGS2 and chronic myelogenous leukemia, BCR-ABL1 positive: In human chronic myelogenous leukemia K562 cells and HEL cell apoptosis studies, it has been found that G0/G1 cells are more prone to apoptosis, and diosgenin can increase the expressions of thromboxane synthase (TxS) and cyclooxygenase-2 and induce HEL cell differentiation [37–39].