In Tang et al.’s work, in the absence of opportunistic fungi, a completely different mechanism was proposed, involving decreased levels of the antimicrobial peptides (AMPs) S100a8 and S100a9, impacting the bacterial microbiota and particularly the overgrowth of Lactobacillus murinus in the absence of Dectin-1, which has a positive effect on Treg cells and consequently on colitis development [7]. This evidence concerns the gene CLEC7A and colitis.