Interestingly, in the present study, we analyzed several chromatin disorders, such as Coffin-Lowry (CLS, MIM#303600) (Fig. 1 B), Coffin-Siris 1 (CSS1, MIM#135900), Koolen de-Vries (KdVS, MIM#610443), (Fig. 1 B), White-Sutton (WHSUS, MIM#616364), Kabuki (KABUK1, MIM#147920), Kleefstra 1 (KLEFS1, MIM#610253) and KBG syndromes (KBGS, MIM#148050), which are characterized by a similar facial gestalt. The gene discussed is KMT2D; the disease is KBG syndrome.