Among the 55 patients with MEN1-related insulinoma, the mean age at the first episode of HH was 30.76 ± 14.03 years (range 9–75 years), and that at the time of diagnosis of insulinoma and MEN1 was 34.49 ± 14.99 and 36.20 ± 14.08 years, respectively (Table 1). This evidence concerns the gene MEN1 and pancreatic insulinoma.