MEN1 and pancreatic insulinoma: This study aimed to analyze the clinical data of patients with MEN1-associated insulinoma treated at the Peking Union Medical College Hospital (PUMCH) from January 2002 to August 2021 and to explore the impact of biochemical changes caused by the presence of hypercalcemia on their clinical features to provide insights into screening, management, and follow-up strategies for this rare disease.