The stimulation of GM-CSF to ARDS neutrophils further increased NET formation (Fig. 7A and B, GM-CSF + PMA group vs. PMA group, p < 0.0001); this effect was reversed by AT7519 (Fig. 7A and B; GM-CSF + AT7519 + PMA group vs. GM-CSF + PMA group, p < 0.0001). Here, CSF2 is linked to acute respiratory distress syndrome.