In this study, we noticed that CDH1, CCL11, HLA–DRA, NOS2, NAT2 and TIMP1 exhibited significant positive or negative correlation with the infiltration of multiple immune cells in COAD and READ, such as B cells, CD8 + T cells, CD4 + T cells, macrophages, neutrophils or dendritic cells, except for TP53. The gene discussed is CD4; the disease is colon adenocarcinoma.