Then, through LASSO Cox regression analysis, we screened out 7 prognostic genes, including CDH1, CCL11, HLA–DRA, NOS2, NAT2, TIMP1 and TP53 from IBDGs which differentially expressed in CRC tumor and normal tissue, and significantly related to pathological stages and prognosis of CRC patients. The gene discussed is TIMP1; the disease is neoplasm.