To explore the pathways mediated by the CDH1, CCL11, HLA–DRA, NOS2, NAT2, TIMP1 and TP53, we collected 100 most frequently altered neighbor genes of the 7 prognostic genes in CRC from GEPIA database, and KEGG pathway analysis was performed using KOBAS online tool. This evidence concerns the gene HLA-DRA and colorectal carcinoma.