Then, through LASSO Cox regression analysis, we screened out 7 prognostic genes, including CDH1, CCL11, HLA–DRA, NOS2, NAT2, TIMP1 and TP53 from IBDGs which differentially expressed in CRC tumor and normal tissue, and significantly related to pathological stages and prognosis of CRC patients. This evidence concerns the gene TP53 and neoplasm.