For 13 hematological indices, we found evidence of causal effects on CAD for RBC (OR = 1.21 per 40.94×104/μL increment, 1.10–1.33, P = 9.46×10−5), Hb (1.28 per 1.23 g/dL increment, 1.11–1.47, P = 4.87×10−4), and Ht (1.31 per 3.53% increment, 1.16–1.48, P = 1.18×10−5) in East Asians, with similar results yielded by different MR methods (Tables 1 and 2, Fig. 3B, Additional file 1: Table S7). Here, GSTM1 is linked to coronary artery disorder.