None of the 7 hepatic function biomarkers showed significant causal effects on CAD, including total bilirubin (TBil), aspartate aminotransferase (AST), alanine aminotransferase (ALT), alkaline phosphatase (ALP), γ-glutamyl transferase (GGT), TP, and serum albumin (Alb). The gene discussed is GPT; the disease is coronary artery disorder.