EGFR and bone metastasis: Furthermore, in patients with bone metastasis, the PFS of the osimertinib group was significantly longer than that of the gefitinib/erlotinib group (17.0 vs. 8.6 months; Wilcoxon P < 0.0001 and log-rank P < 0.0001; Fig. 4C) and showed a better trend compared with those of the patients in the afatinib group (17.0 vs. 12.9 months; Wilcoxon P = 0.1884 and log-rank P = 0.1144; Fig. 4C), although the OS demonstrated no significant differences among the three EGFR-TKI groups (Fig. 4D).