This argumentation was challenged by others, claiming that the fear of hypoglycemia, both by healthcare professionals and patients, was probably more relevant than the actual risk of hypoglycemia.But I doubt if it [choosing glargine 100 U/ml instead of NPH insulin because of the risk of hypoglycemia] is because of the fear rather than the actual risk of nocturnal hypoglycemia. This evidence concerns the gene INS and Hypoglycemia.