ADCYAP1 and migraine disorder: We found that the PACAP-38 levels of migraine group were notably higher than those of control group (Fig. 3a) (PACAP-38(m) = 41.32 ± 5.49 ng/ml, PACAP-38(c) = 33.44 ± 4.92 ng/ml, p < 0.001).