Moreover, there was a high AUC, the best sensitivity, and a higher OR of CGRP and PACAP-38, suggesting that CGRP and PACAP-38 are good indicators to diagnose pediatric migraine, and the combination of CGRP and PACAP-38 has a great value in diagnosing pediatric migraine and distinguishing migraine and non-migraine headache in terms of the largest AUC and specificity. Here, ADCYAP1 is linked to Headache.