ADCYAP1 and migraine disorder: There was a tendency for plasma PACAP-38 levels to increase in the ictal period of migraine patients with aura, but no difference was found between the two groups (Fig. 4b) (PACAP-38(ictal) = 41.46 ± 4.56 ng/ml, PACAP-38 (interictal) = 40.32 ± 7.38 ng/ml, p > 0.05).