ADCYAP1 and migraine disorder: There were higher PACAP-38 levels in the migraine with aura and without aura groups than in the control group (Fig. 3c) (PACAP-38(MWA) = 40.83 ± 5.99 ng/ml, PACAP-38(MWoA) = 41.97 ± 5.26 ng/ml, PACAP-38(c) = 33.44 ± 4.92 ng/ml, p < 0.001).