PDE9A and diabetes mellitus: In the discovery search (stage 1, nDM = 109,993; nnoDM = 1,070,999), we identified four eGFR loci with significant DM/noDM-difference (Supplementary Fig. 1): (i) two by the difference test approach (rs77924615 near UMOD-PDILT, rs12233328 near PDE9A; PDiff < 5 × 10−8, Supplementary Data 2), and (ii) two further loci by the overall+difference test approach (near TPPP and MED1-NEUROD2;POverall < 5 × 10−8 and PDiff < 0.05/610 = 8.2 × 10−5; corrected for 610 followed variants16, Supplementary Data 2).