CUBN and diabetes mellitus: The identified CUBN locus eGFR lead variant, rs11254238, showed (i) no correlation with the known signals for UACR (r2 < 0.001, D’ > 0.24 to any of the known independent signal variants for UACR, rs141493439, rs45551835, rs557338857, rs562661763, rs74375025), (ii) no effect on UACR41 (P = 0.57, Supplementary Data 6), and (iii) a twice as large effect on eGFR in DM compared to noDM, but the difference was not significant (bDM = 0.0048, bnoDM = 0.0021, PDiff = 0.07).