There was no significant difference between the two groups’ baseline severity scores (i.e., APACHE II, and SOFA scores), the needs for MV within 24 h (early: 61.5% vs. late: 59.6%, p = 0.77), baseline Oxygenation Index (OI) (early: 16.3 vs. late: 17.3, p = 0.30), PaO2/FiO2 ratio (median 83.1 in the early group vs. 79.5 in the late group, p = 0.55), blood glucose level, lactic acid, platelets count, CRP, Creatine phosphokinase (CPK), ferritin, procalcitonin, eGFR and AKI status within 24 h of ICU admission (early 31.7% vs. late 26.9%, p = 0.4463) after using propensity score. The gene discussed is CRP; the disease is acute kidney injury.