MYC and breast carcinoma: Because MYC dysregulation is a known mechanism of global transcriptional amplification across cancers, we first evaluated the relationship between TmS and MYC expression and found a positive correlation in several cancer types53, including breast carcinoma and renal papillary carcinoma (Spearman r = 0.17 and 0.21, respectively; Supplementary Note 2.3.2).