In contrast, some phenotypes in microcephaly organoids were detected irrespective of the method, such as a decline in ventricular versus neuronal area ratios judged by SOX2 and DCX, respectively (Extended Data Fig. 9c), as well as the accumulation of dividing cells within apical ventricular linings (Extended Data Fig. 9d), implying increased neurogenesis and cell-cycle defects. The gene discussed is SOX2; the disease is microcephaly.