A recent retrospective analysis of a large cohort of non-metastatic, non-IBC, primary invasive breast cancer samples for the apoptotic regulator, XIAP, revealed that XIAP mRNA expression is independently associated with poor outcomes and lower pathological complete response (pCR) to anthracycline-bsed neoadjuvant chemotherapy45. The gene discussed is XIAP; the disease is invasive breast carcinoma.