RENBP and atrial fibrillation: The pathways of action were clarified by KEGG enrichment analysis of 65 intersecting genes, with 157 enrichment terms, of which the top 30 most significant pathways (Fig. 4a), the core targets may affect the lipid and atherosclerosis, AGE-RAGE signaling pathway in diabetic complications, MAPK signaling pathway, and IL-17 signaling pathway, suggesting that Que may be effective in treating AF by modulating the above signaling pathways.