GO analysis confirmed that Que had the potential to play an important role in the pathogenesis of AF through multiple biological pathways, and KEGG analysis obtained key pathways of Que for AF, mainly involving lipid and atherosclerosis pathways, the AGE-RAGE signaling pathwayin diabetic complications, MAPK signaling pathway and IL-17 signaling pathway, etc. Through further screening, we found that MAPK pathway plays a key role in the treatment of AF. The gene discussed is IL17A; the disease is atherosclerosis.