In the 1980s, Knauf et al.11 first discovered the expression of CD47 on ovarian cancers, subsequently, a series of studies have confirmed that CD47 is overexpressed on tumor cells compared with healthy cells, including acute lymphoblastic leukemia cells12, lymphoma cells7, non-Hodgkin’s lymphoma (NHL) cells13, glioblastoma14, myeloma cells15, bladder tumor cells16, head and neck squamous cell carcinoma cells17, breast18, pancreas19, liver20, lung21, and prostate cancer cells22. Here, CD47 is linked to head and neck squamous cell carcinoma.