The genes RPL5 and RPS6, encoding ribosomal proteins, are, after GLTSCR2, the most significantly down regulated genes when comparing all Pure DCIS samples with all normal ductal tissue, (FC; 1.3e-66 and 1.1e-57 respectively), and both genes were also among the most significant DEGs when comparing samples from very early in the PCP continuum. This evidence concerns the gene RPS6 and ductal breast carcinoma in situ.