RNA-seq analysis of RNF138-deficient models and in-depth data analysis revealed NF-кB signaling as the key target of RNF138 whereas other CRC-correlated genetic pathways, such as Wnt signaling and STAT3 signaling, were not remarkably altered with RNF138 depletion (Supplementary Fig. S10c–f). Here, RNF138 is linked to colorectal carcinoma.