RNF138 and neoplasm: The reduction in RNF138 expression was found specifically associated with more aggressive tumor phenotypes (P = 0.027), reflected by both the increase in the size and extent of primary tumors (P = 0.003) and lymph node invasion (P = 0.003), while no significant correlation was observed with CRC tumor metastasis (P = 0.246) (Supplementary Fig. S2b–d; Supplementary Table 4).