Specifically, the CRC patients were stratified into four groups based on the level of RNF138 and the pp65 N/C ratio, i.e., RNF138high-pp65 N/C ratiolow, RNF138low-pp65 N/C ratiohigh, RNF138high-pp65 N/C ratiohigh, and RNF138low-pp65 N/C ratiolow. The gene discussed is RNF138; the disease is colorectal carcinoma.